Ethambutol + Isoniazid + Pyrazinamide + Rifampicin
Uses of Ethambutol + Isoniazid + Pyrazinamide + Rifampicin
This medication combination is used in the treatment of tuberculosis (TB), belonging to the class of anti-infectives.
How Ethambutol + Isoniazid + Pyrazinamide + Rifampicin Works
Each component targets different aspects of TB bacteria. Ethambutol inhibits the synthesis of the bacterial cell wall, isoniazid disrupts mycolic acid synthesis, pyrazinamide interferes with fatty acid metabolism, and rifampicin inhibits RNA synthesis, collectively suppressing bacterial growth.
Side Effects of Ethambutol + Isoniazid + Pyrazinamide + Rifampicin
Common side effects may include gastrointestinal disturbances, hepatotoxicity, peripheral neuropathy, and optic neuritis. Less common but severe side effects can include liver damage, allergic reactions, and blood disorders. Prompt medical attention is necessary if any adverse reactions occur.
Warnings
Kidney Limited Data
Limited data are available regarding the impact of this medication combination on kidney function. Consultation with a healthcare professional is recommended for individuals with kidney issues.
Alcohol Limited Data
Limited data are available regarding the interaction of this medication combination with alcohol. It is advisable to use caution and consult a healthcare professional before consuming alcohol while taking this medication.
Pregnancy Safe If Prescribed
This medication combination is considered safe if prescribed during pregnancy, with potential risks and benefits evaluated by a healthcare provider.
Driving Use With Care
Caution is advised while driving or operating machinery, as this medication combination may cause dizziness or visual disturbances. It is essential to assess individual response before engaging in activities that require alertness.
Liver High Risk
This medication combination poses a high risk of liver toxicity. Close monitoring of liver function is essential during treatment, and caution is advised, especially for individuals with pre-existing liver conditions.
Lactation Limited Data
Limited data are available regarding the safety of this medication combination during lactation. Consultation with a healthcare professional is advised to determine potential risks and benefits.