Ethambutol + Isoniazid + Pyrazinamide + Rifampicin

Uses of Ethambutol + Isoniazid + Pyrazinamide + Rifampicin

This medication combination is used in the treatment of tuberculosis (TB), belonging to the class of anti-infectives.

How Ethambutol + Isoniazid + Pyrazinamide + Rifampicin Works

Each component targets different aspects of TB bacteria. Ethambutol inhibits the synthesis of the bacterial cell wall, isoniazid disrupts mycolic acid synthesis, pyrazinamide interferes with fatty acid metabolism, and rifampicin inhibits RNA synthesis, collectively suppressing bacterial growth.

Side Effects of Ethambutol + Isoniazid + Pyrazinamide + Rifampicin

Common side effects may include gastrointestinal disturbances, hepatotoxicity, peripheral neuropathy, and optic neuritis. Less common but severe side effects can include liver damage, allergic reactions, and blood disorders. Prompt medical attention is necessary if any adverse reactions occur.

Warnings

Kidney Limited Data

Limited data are available regarding the impact of this medication combination on kidney function. Consultation with a healthcare professional is recommended for individuals with kidney issues.

Alcohol Limited Data

Limited data are available regarding the interaction of this medication combination with alcohol. It is advisable to use caution and consult a healthcare professional before consuming alcohol while taking this medication.

Pregnancy Safe If Prescribed

This medication combination is considered safe if prescribed during pregnancy, with potential risks and benefits evaluated by a healthcare provider.

Driving Use With Care

Caution is advised while driving or operating machinery, as this medication combination may cause dizziness or visual disturbances. It is essential to assess individual response before engaging in activities that require alertness.

Liver High Risk

This medication combination poses a high risk of liver toxicity. Close monitoring of liver function is essential during treatment, and caution is advised, especially for individuals with pre-existing liver conditions.

Lactation Limited Data

Limited data are available regarding the safety of this medication combination during lactation. Consultation with a healthcare professional is advised to determine potential risks and benefits.

Written by , MD (Universiti Hasanuddin, Indonesia)

Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).

  • Products

    Available medicines with Ethambutol + Isoniazid + Pyrazinamide + Rifampicin
  •