Etonogestrel
Uses of Etonogestrel
Etonogestrel is commonly used as birth contraceptive in the form of vaginal ring or subdermal implant.
How Etonogestrel Works
Etonogestrel is the active metabolite of desogestrel with high affinity towards progesterone receptors. It prevents pregnancy by inhibiting ovulation, thickens the cervical mucus and inhibiting thickening of the endometrium.
Side Effects of Etonogestrel
Menstrual irregularities, Nausea, Vomiting, Headache, Dizziness, Breast discomfort, Enlarged breast in men, Mood lability, Fluid retention, Weight gain, Changes in libido, Hair loss, Hirsutism.
Warnings
Kidney Use With Care
Etonogestrel should be used with caution in patients with kidney disease as it may cause fluid retention. Dose adjustment of Etonogestrel may be needed. Please consult your doctor before using it.
Alcohol Not Advisable
Alcohol can potentiate the side effects of Etonogestrel; dizziness, nausea, and stomach pain. Thus, you're not advisable to drink alcohol while on this contraceptive.
Pregnancy Limited Data
Etonogestrel may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies. Users are prohibited from using Etonogestrel once suspected of pregnancy. Please consult your doctor before using it.
Driving Generally Safe
Etonogestrel may cause negligible to no side effects which could affect your ability to concentrate and drive.
Liver Limited Data
Etonogestrel is metabolized primarily in the liver. It is contraindicated for us in patients with liver disease. Please consult your doctor before using it.
Lactation Limited Data
If indicated during lactation, Etonogestrel is safe for usage as contraceptive method starting from 4th week of postpartum. Based on limited human data, a small amount of Etonogestrel is excreted into breast milk but Etonogestrel does not represent a significant risk to the baby.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
