Exemestane
Uses of Exemestane
Exemestane is commonly used to treat advanced breast cancer in postmenopausal patients with positive hormone receptor.
How Exemestane Works
Exemestane is an irreversible, selective aromatase inhibitor. It prevents the conversion of androgens to oestrogens in peripheral tissues thereby lowering circulating of oestrogens in postmenopausal women with breast cancers where growth is oestrogen-dependent.
Side Effects of Exemestane
Low white blood cell, Depression, Insomnia, Headache, Dizziness, Hot flushes, Abdominal pain, Nausea, Increased sweating, Joint pain, Musculoskeletal pain, Pain, Fatigue
Warnings
Kidney Use With Care
Exemestane should be used with caution in patients with kidney disease. Dose adjustment of Exemestane may be needed. Please consult your doctor before using it.
Alcohol Safe
Consuming alcohol will not affect the pharmacokinetics of Exemestane. There might be drug interactions between alcohol and Exemestane so please consult your doctor before using it.
Pregnancy Not Safe - High Risk
Exemestane is contraindicated for use in pregnant women because it may cause harmful effects to the fetus. Animal studies have shown reproductive toxicity.
Driving Not advisable
Exemestane may cause side effects of dizziness and headaches, all of which could affect your ability to concentrate and drive. Do not drive unless you are feeling well.
Liver Limited Data
Exemestane should be used with caution in patients with liver disease. Dose adjustment of Exemestane may be needed. Please consult your doctor before using it.
Lactation Limited Data
It is unknown whether Exemestane is excreted into human breast milk and there is no conclusive studies on its effect on the feeding baby. Breastfeeding mother is advised to withhold breastfeeding while on Exemestane.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
