Fenofibrate + Simvastatin
Uses of Fenofibrate + Simvastatin
This medication combination is utilized for the management of lipid disorders, particularly hypercholesterolemia and hypertriglyceridemia, in order to reduce the risk of cardiovascular events.
How Fenofibrate + Simvastatin Works
Fenofibrate works by decreasing the production of triglycerides and increasing the levels of HDL cholesterol. Simvastatin, on the other hand, inhibits the enzyme HMG-CoA reductase, thereby reducing the production of cholesterol in the liver.
Side Effects of Fenofibrate + Simvastatin
Common side effects may include headache, nausea, diarrhea, and muscle pain. Less common but serious side effects can include liver problems, muscle breakdown, and increased blood sugar levels. Consult a healthcare professional if any severe side effects occur.
Warnings
Kidney Limited Data
Limited data are available regarding the impact of this medication combination on kidney function. Consultation with a healthcare professional is recommended for individuals with kidney issues.
Alcohol Limited Data
Limited data are available regarding the interaction of this medication combination with alcohol. Caution is advised, and it is recommended to consult with a healthcare professional before combining the two.
Pregnancy Not Safe - High Risk
This medication combination is not safe during pregnancy and carries a high risk of harm to the fetus. It should be avoided unless the benefits outweigh the risks and under the supervision of a healthcare professional.
Driving Use With Care
Caution is advised while driving or operating machinery, as this medication may cause dizziness or drowsiness. It is essential to assess individual response before engaging in activities that require alertness.
Liver High Risk
This medication combination carries a high risk of liver problems. Regular monitoring of liver function is essential, and caution is advised, especially in individuals with pre-existing liver conditions.
Lactation Limited Data
Limited data are available regarding the safety of this medication combination during lactation. Consultation with a healthcare professional is advised to determine potential risks and benefits.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
