Fosfomycin

Uses of Fosfomycin

Fosfomycin is commonly used to treat Bacterial Infections Of Urinary Tract

How Fosfomycin Works

Fosfomycin works by inhibiting the bacterial cell wall synthesis by stopping the peptidoglycan formation. The bacterial cell wall loses its integrity and hence died because of osmolarity difference.

Side Effects of Fosfomycin

Nausea, Diarrhea, Headache, Visual disturbance, Skin rashes, Jaundice

Warnings

Kidney Use With Care

Fosfomycin is excreted via urine and dosage adjustment is needed in patients with renal impairment.

Alcohol Safe

There is no clear contraindication of the consumption of alcohol when taking Fosfomycin.

Pregnancy Maybe Safe

Animal studies have been shown to be safe for fetal development but no adequate data to suggest the same on human pregnancy study or to suggest harm either. Caution should be taken when commencing someone on Fosfomycin during pregnancy.

Driving Not advisable

It is not advisable to drive when taking Fosfomycin due to its potential side effects such as headache and visual disturbance which can affect the ability to drive and concentrate.

Liver Limited Data

There is no need for dosage adjustment according to the manufacturer labelling as Fosfomycin is not metabolised by the liver.

Lactation Limited Data

Fosfomycin has been found in human breastmilk but there is limited human data to suggest harm to the breastfed infants. It should be used only if there are no other alternatives.

Frequently Asked Questions

Written by , MD (Universiti Hasanuddin, Indonesia)

Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).