Gemfibrozil
Uses of Gemfibrozil
Gemfibrozil is commonly used to treat High Cholesterol, High Triglycerides
How Gemfibrozil Works
Gemfibrozil is a derivative of fibric acid. The mechanism of action is not yet fully understood. It decreases the liver synthesis of VLDL and LDL cholesterols (the bad cholesterols) and increases the HDL (the good cholesterol).
Side Effects of Gemfibrozil
Muscle weakness, Dizziness, Drowsiness, Headache, Fatigue, Taste disturbance, Nausea, Vomiting, Reduced libido, Blurred vision
Warnings
Kidney High Risk
Dosage adjustment is needed in mild to moderate renal impaired patients and is contraindicated to be used in patients with severe renal impairment.
Alcohol Not Advisable
It is not advisable to drink alcohol when taking Gemfibrozil treatment as to avoid alcohol abuse which can precipitate rhabdomyolysis.
Pregnancy Not Safe
There is only limited animal and human reproductive while the former suggests reproductive risk. Gemfibrozil should only be used if the benefits outweigh the risks.
Driving Not advisable
It is not advisable to drive when on Gemfibrozil due to its potential side effects such as drowsiness, dizziness and headache which can affect the ability to drive and concentrate.
Liver Limited Data
It is contraindicated for Gemfibrozil to be used in patients with hepatic impairment.
Lactation Limited Data
Gemfibrozil is not known whether to present in the human breastmilk or not. It advisable to stop breastfeeding or the treatment due to its potential toxicity.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
