Hydroxyurea
Uses of Hydroxyurea
Hydroxyurea is commonly used to treat Blood Cancer such as Acute and chronic Myeloid Leukemia, Head And Neck Cancer and Sickle Cell Anemia
How Hydroxyurea Works
Hydroxyurea inhibits an enzyme used to prevent the DNA formation. It interrupts with the cell cycle during cell division and sensitizes radiation activity. In sickle cell anemia, hydroxyurea increases red blood cell fetal hemoglobin levels, RBC water content, deformability of sickled cells, and alters adhesion of RBCs to endothelium.
Side Effects of Hydroxyurea
Reduced appetite, Skin cancer, Frequent infections due to bone marrow failure, Hallucination and disorientation, Dizziness, Somnolence, Difficulty breathing, Rash, Fatigue, Reduced fertility in men
Warnings
Kidney Use With Care
Hydroxyurea should be used with caution in patients with severe kidney disease. Dose adjustment of Hydroxyurea may be needed hence frequent renal function monitoring is required. Please consult your doctor.
Alcohol Safe
It is safe to consume alcohol with Hydroxyurea as there is no drug interactions.
Pregnancy Limited Data
Hydroxyurea may be unsafe to use during pregnancy as it can cause fetal harm. It has been proven to have teratogenic effects in animals.
Driving Not advisable
Hydroxyurea may cause side effects such as dizziness, headaches and tiredness, all of which could affect your ability to concentrate and drive.
Liver Use With Care
Liver function monitoring is required prior to commencement of treatment.
Lactation Not Advisable
Hydroxyurea is not safe to be used during lactation as it is excreted in human milk.