Lamotrigine

Uses of Lamotrigine

Lamotrigine is commonly used to treat Bipolar Disorder, Epilepsy, Epileptic seizures, Mania, Migraine, Seizures, Trigeminal Neuralgia

How Lamotrigine Works

Lamotrigine is an anticonvulsant agent. It stabilises presynaptic neuronal membranes by blocking voltage sensitive Na channels, subsequently inhibiting the release of neurotransmitters involved in the generation and spread of epileptic seizures.

Side Effects of Lamotrigine

Aggression, Irritability, Difficulty sleeping (insomnia), Headache, Tremor Somnolence, Nausea and vomiting, Joint pain, Fatigue, Rash

Warnings

Kidney Use With Care

Caution should be exercised when patients with renal failure take Lamotrigine. Dose adjustment of Lamotrigine may be needed. Please consult your doctor.

Alcohol Not Advisable

It is unsafe to consume alcohol with Lamotrigine. Taking Lamotrigine with alcohol may have additive effects in central nervous system. It increases the risk of CNS depression.

Pregnancy Not Safe

Lamotrigine may be unsafe to use during pregnancy. Nevertheless, sudden discontinuation will lead to detrimental effect to both fetus and mother. Monotherapy is better than multiple antiepileptic commencement as they reduce the risk of congenital malformation.

Driving Limited Data

There is no study regarding the influence of Lamotrigine on the ability to drive. Nevertheless, there are reported cases of double vision and dizziness whilst driving. Therefore, patients should not drive if such adverse effects happen.

Liver Use With Care

Lamotrigine should be used with caution in patients with liver disease. Dose titration of Lamotrigine may be needed according to level of liver deterioration. Please consult your doctor.

Lactation Not Advisable

Lamotrigine may be unsafe to use during lactation as there are risks of sedation, poor weight gain and rash if administered due to the potential benefits of breast-feeding outweigh the potential risk of adverse effects occurring in the infant.