Linagliptin
Uses of Linagliptin
Linagliptin is commonly used to treat Type 2 Diabetes Mellitus
How Linagliptin Works
Linagliptin is an antidiabetic medication. It inhibits an enzyme, dipeptidyl peptidase-4 (DPP-4) which is involved in the inactivation of the incretin hormones causing it to become more active and higher in concentration. Both incretin hormones are involved in the physiological regulation of glucose homeostasis.
Side Effects of Linagliptin
Low sugar level, Severe joint pain, Rash, Mouth ulcer, Diarrhea, Cough
Warnings
Kidney Safe If Prescribed
Linagliptin can be used in patients with kidney disease. No dose adjustment of Linagliptin may be needed. Please consult your doctor.
Alcohol Not Advisable
It is unsafe to consume alcohol with Linagliptin as there is no information regarding Linagliptin interactions.
Pregnancy Limited Data
Use of Linagliptin should be avoided during pregnancy. Animal studies have shown no adverse effects on the fetus, and it is not yet being studied in pregnant women.
Driving Not advisable
Linagliptin has no or negligible influence on the ability to drive. Nevertheless, patients should be alerted to the risk of low blood sugar if it is taken with sulphonylurea or Linagliptin.
Liver Use With Care
Linagliptin can be used with caution in patients with liver disease. No dose adjustment of Linagliptin may be needed. Please consult your doctor.
Lactation Not Advisable
A risk to nursing infant cannot be excluded as there is no information regarding the excretion in human milk. Therefore, Linagliptin is probably unsafe to use during lactation.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
