Naltrexone
Uses of Naltrexone
How Naltrexone Works
Naltrexone inhibits the action of opioids by acting as a competitive inhibitor at the opioids receptor site. This action precipitates opioids withdrawal symptoms in opioids dependent individuals.
Side Effects of Naltrexone
Pain in the abdomen, Nausea & Vomiting, Diarrhea, Constipation, Feeling anxious, Insomnia, Headache, Muscle pain, Chest pain, Chills, Dizziness
Warnings
Kidney High Risk
Naltrexone is contraindicated in patients with severe kidney impairment
Alcohol Not Advisable
Naltrexone is used to treat alcohol addiction. Taking Naltrexone with alcohol will accentuate the withdrawal symptoms of opioids and makes the patients feeling worst.
Pregnancy Not Safe
Study of Naltrexone administration in the animal has shown some adverse effects to the pregnant mother and embryo. However, no controlled studies had been done in humans. Administration of this medication during pregnancy should only be done only if the benefits outweigh the risks.
Driving Not advisable
Naltrexone may cause a significant effect on the psychological & physical abilities of the user. Therefore avoid driving or operating machines while taking this medication.
Liver Limited Data
Naltrexone is contraindicated in patients with severe liver impairment
Lactation Limited Data
No data are available for the safety of Naltrexone use during breastfeeding. It is unknown whether this medication is excreted in breast milk. It is not recommended to use this medication while breastfeeding.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
