Nintedanib
Uses of Nintedanib
Nintedanib is commonly used to treat Idiopathic Pulmonary Fibrosis and Non Small Cell Lung Cancer,
How Nintedanib Works
Nintedanib blocks the multiple receptor tyrosine kinases and nonreceptor tyrosine kinases by binding completely to their ATP binding pockets which will inhibit the intracellular signaling.
Side Effects of Nintedanib
Diarrhea, Nausea, Vomiting, Abdominal pain, Decrease appetite, Dehydration, Electrolyte disturbance, Headache, Rash, Febrile neutropenia
Warnings
Kidney Use With Care
Dose adjustment is needed with the patient with kidney impairments
Alcohol Safe
It is safe to consume alcohol with Nintedanib. However one should always limit their alcohol intake.
Pregnancy Not Safe
Animal studies show Nintedanib carries potential risk towards the human fetus. This medication is advised to be discontinued during pregnancy unless the benefits outweigh the risks.
Driving Not advisable
Nintedanib may cause minor impairment in the ability of driving and operating machines. Only drive if you are feeling well.
Liver Limited Data
Treatment with Nintedanib is not recommended in patient with liver impairment
Lactation Limited Data
Animal studies show that a small amount of Nintedanib and its metabolites are excreted in breastmilk. This medication should not be administered during breastfeeding.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
