Ondansetron
Uses of Ondansetron
Ondansetron is commonly used to treat nausea and vomiting due to chemotherapy, radiotherapy or post- surgery.
How Ondansetron Works
Ondansetron is blocks 5-HT3-receptor on both vagal nerve terminals in the periphery and in the brain’s chemoreceptor trigger zone or also known as the vomitting centre.
Side Effects of Ondansetron
Headache, Flushing, Constipation, ECG changes, Rash
Warnings
Kidney Safe If Prescribed
The pharmacokinetics of Ondansetron is not significantly affected in patients with kidney disease. Dose adjustment of Ondansetron may not be needed. Please consult your doctor before using it.
Alcohol Safe
There's no known drug interactions between alcohol consumption and Ondansetron. However, do consult your doctor before using it.
Pregnancy Maybe Safe
Ondansetron may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies. Please consult your doctor before using it.
Driving Generally Safe
Ondansetron cause minimal to no side effects which could affect your ability to concentrate and drive.
Liver Limited Data
Ondansetron should be used with caution in patients with moderate to severe liver disease. Dose adjustment of Ondansetron may be needed. Please consult your doctor before using it.
Lactation Limited Data
Ondansetron is excreted into the breastmilk of animals however there is inadequate data on human studies. Hence, it is not recommended for use during pregnancy. Please consult your doctor before using it.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
