Palbociclib
Uses of Palbociclib
Palbociclib is commonly used to treat hormone receptor positive breast carcinoma.
How Palbociclib Works
Palbociclib is a reversible, selective inhibitor of cyclin-dependent kinase (CDK) 4 and 6. Cyclin D1, CDK 4 and 6 are enzymes in the multiple signalling pathways of tumour cell proliferation. Therefore, blocking progression from G1 into S phase of the cell cycle.
Side Effects of Palbociclib
Low white blood cell count, Susceptible to infections, Fatigue, Nausea, Stomatitis, Low red blood cell count, Alopecia, Rash, Diarrhea, Vomiting, Decreased appetite, Vision blurred
Warnings
Kidney Safe If Prescribed
Palbociclibs's pharmacodynamic is not significantly affected in patients with kidney disease. Dose adjustment of Palbociclib may not be needed. Please consult your doctor before using it.
Alcohol Safe
Consuming alcohol in moderation does not seem to cause pharmacodynamic changes with Palbociclib. However, please consult your doctor before using it,
Pregnancy Limited Data
Palbociclib may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The medication is not recommended for use in pregnant women. Please consult your doctor before using it.
Driving Not advisable
Palbociclib may cause side effects of blurred vision and fatigue all of which could affect your ability to concentrate and drive. Do not drive unless you are feeling well.
Liver Limited Data
Palbociclib should be used with caution in patients with mild to moderate liver disease. Dose adjustment of Palbociclib may be needed in severe liver disease. Please consult your doctor before using it.
Lactation Limited Data
Data of Palbociclib excretion into breast milk and its potential adverse effect on feeding baby is largely unknown. Please consult your doctor before using it.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
