Paliperidone

Uses of Paliperidone

Paliperidone is commonly used to treat schizophrenia and schizoaffective disorder in the adolescent and adults.

How Paliperidone Works

Paliperidone is an atypical antipsychotic which inhibits dopamine D2, serotonin (5-HT2A), adrenergic (α1 and α2), and histamine (H1) receptors. It also causes less catalepsy and motor functions than traditional neuroleptics. It also causes less extrapyramidal side effects.

Side Effects of Paliperidone

Headache, Insomnia, Sedation/somnolence, Parkinsonism, Akathisia, Increased heart rate, Tremor, Dystonia, Upper respiratory tract infection, Anxiety, Dizziness, Weight increased, Nausea, Agitation, Constipation, Vomiting, Fatigue, Depression, Dyspepsia, Diarrhea, Dry mouth, Toothache, Musculoskeletal pain, Increased blood pressure, Back pain, Cough.

Warnings

Kidney Use With Care

Paliperidone should be used with caution in patients with kidney disease. Dose adjustment of Paliperidone may be needed. Please consult your doctor before using it. Use of Paliperidone is not recommended in patients with end-stage kidney failure.

Alcohol Not Advisable

Consuming alcohol can potentiate the effects of CNS depressant caused by Paliperidone. Please consult your doctor before using it.

Pregnancy Not Safe

Paliperidone may be unsafe to use during pregnancy. There are limited animal and human studies to show adverse effects on the pregnancy. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor before using it.

Driving Not advisable

Consuming alcohol can potentiate the effects of CNS depressant caused by Paliperidone which could affect your ability to concentrate and drive. Do not drive unless you are feeling well.

Liver Use With Care

Paliperidone should be used with caution in patients with liver disease. Dose adjustment of Paliperidone may be needed. Please consult your doctor before using it.

Lactation Not Advisable

Paliperidone is excreted into human breast milk. Studies suggest that there is potential adverse effect on feeding baby. Paliperidone is not recommended for use in pregnant women.

Frequently Asked Questions

Written by , MD (Universiti Hasanuddin, Indonesia)

Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).