Perampanel
Uses of Perampanel
Perampanel is commonly used to treat Seizures
How Perampanel Works
Perampanel works by non-competitively antagonize the AMPA glutamate receptor of the post-synaptic neurons and reduce neuronal excitation by blocking glutamate in the central nervous system.
Side Effects of Perampanel
Dizziness, Somnolence, Fatigue, Drowsiness, Vertigo, Anxiety, Confusion, Nausea, Vomiting, Blurred vision
Warnings
Kidney High Risk
Perampanel should be used with caution in people with mild renal impairment and is contraindicated for those with moderate to severe renal impairment.
Alcohol Not Advisable
Consuming alcohol when taking Perampanel is strictly contraindicated due to potential worsening of side effect on the central nervous system.
Pregnancy Limited Data
Animal reproductive studies did not indicate fetal harm or toxicity but do show embryological toxicity. Human pregnancy data is limited and thus it is not recommended for Perampanel to be used during pregnancy.
Driving Not advisable
It is not advisable to drive when under Perampanel treatment due to its potential side effects such as fatigue and dizziness which can affect the ability to concentrate and drive.
Liver Limited Data
Perampanel should be used with caution in people with mild to moderate hepatic impairment together with dosage adjustment and is contraindicated for those with severe hepatic impairment.
Lactation Limited Data
It is not known whether Perampanel is excreted into human breastmilk or not. Due to its potential toxicity, Perampanel is not advisable to be used during breastfeeding. If being used during breastfeeding, alternative to the latter should be sought.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
