Pirfenidone
Uses of Pirfenidone
Pirfenidone is commonly used to treat Idiopathic Pulmonary Fibrosis
How Pirfenidone Works
Pirfenidone is an immunosuppressants. It is an antifibrotic agent that works by decreasing the amount of inflammatory cells and factors that were found in high amounts in patients with fibrosis
Side Effects of Pirfenidone
Nausea/ vomiting, Diarrhea, Indigestion, Abdominal pain, Weight loss, Dizziness
Warnings
Kidney Use With Care
Pirfenidone can be used with caution in patients with mild to moderate kidney disease. However, it is contraindicated in patients with severe kidney disease.
Alcohol Safe
Although taking Pirfenidone with alcohol may be safe, it is only allowed in very small amount.
Pregnancy Limited Data
Although there is no data available on the effect of Pirfenidone on pregnant women, Pirfenidone should be stopped in planning for a pregnancy or even pregnant mothers.
Driving Not advisable
Do not drive unless you are feeling well. Pirfenidone may cause side effects such as fatigue and dizziness, all of which could affect your ability to concentrate and drive.
Liver Limited Data
Pirfenidone cannot be used in patients with liver problems.
Lactation Limited Data
It is not known about Pirfenidone effect and excretion in human milk, but animal studies has suggested that the medication is found in the milk.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
