Piroxicam
Uses of Piroxicam
Piroxicam is commonly used to treat Ankylosing Spondylitis, Arthralgia Joint Pain, Dental Pain, Eye Pain, Gout, Mouth Ulcers, Musculoskeletal Pain, Post Operative Pain, and Rheumatic Pain.
How Piroxicam Works
Piroxicam is classified as a Non-steroidal Anti-inflammatory Drugs (NSAIDs). It reversibly inhibits cyclooxygenase-1 and -2 (COX-1 and COX-2) enzymes, which decreases the formation of prostaglandin precursors.
Side Effects of Piroxicam
Nausea and vomiting, Anorexia, Hyperglycemia, Heartburn, Altered bowel movement, Bleeding, Headache, Tinnitus, Dizziness, Visual disturbances, Rash, Ankle oedema, Weight gain
Warnings
Kidney Use With Care
Piroxicam should be used with caution in patients with severe kidney disease. Piroxicam plays a role in the maintenance of renal perfusion in patients whose renal blood flow and volume are decreased. Thus, Piroxicam may precipitate overt renal decompensation, which is typically followed by recovery to pre-treatment state upon discontinuation of the drug. Thus, careful monitoring of patients with renal disease is needed. Please consult your doctor.
Alcohol Not Advisable
It is unsafe to consume alcohol with Piroxicam due to increased risk of bleeding in your gastric or intestinal lining.
Pregnancy Not Safe
In view of the known effects of NSAIDs on the foetal cardiovascular system (risk of closure of the ductus arteriosus), use in the last trimester of pregnancy is contraindicated. Data from epidemiological studies suggest an increased risk of spontaneous abortion after use of Piroxicam synthesis inhibitors in early pregnancy
Driving Not advisable
Do not drive unless you are feeling well. Piroxicam may cause side effects such as dizziness, drowsiness, tiredness or visual disturbances, all of which could affect the ability to concentrate and drive.
Liver Limited Data
Piroxicam should be used with caution in patients with liver disease because it is metabolized predominantly by liver. Please consult your doctor for dose adjustment.
Lactation Limited Data
Piroxicam is prohibited for use in nursing mothers since safety for such use has not been established in human.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
