Pramipexole
Uses of Pramipexole
Pramipexole is commonly used to treat Parkinson's Disease and Restless Leg Syndrome
How Pramipexole Works
Pramipexole alleviates motor symptoms in Parkinson’s disease by stimulating postsynaptic dopamine activity in the substantial nigra and striatum.
Side Effects of Pramipexole
Insomnia, Confusion, Dyskinesia, Headache, Abnormal dreams, Somnolence, Hallucinations, , Fatigue, Constipation
Warnings
Kidney Use With Care
Dose adjustment may be needed in patients with kidney impairment as the elimination of this medication is dependent on renal function.
Alcohol Not Advisable
It is not recommended to consume alcohol while taking this medication as it may increase its sedative effect.
Pregnancy Not Safe
Pramipexole has shown to have embryotoxic effects in animal studies. The effects on humans during pregnancy have not been investigated. It is not recommended to use this medication in pregnant women unless the benefits clearly outweigh the risks.
Driving Not advisable
Pramipexole can cause hallucinations and somnolence which will greatly impact the ability to drive and operating machines. Patients on this medication should be advised to refrain from driving and operating machines as it may put them in the risk of injury.
Liver Use With Care
No dose adjustment needed in patients with liver impairment
Lactation Not Advisable
Pramipexole treatment inhibits prolactin in humans which will inhibit lactation. It is not recommended to be used in breastfeeding women. If unavoidable, it is suggested for breastfeeding to be discontinued.