Prednisolone
Uses of Prednisolone
Prednisolone is commonly used to treat Allergic Conditions, Arthritis, Asthma, Cancer, Eye Disorders, Nephrotic Syndrome, Rheumatic Disorder, Severe Allergic Reactions, Skin Disorders.
How Prednisolone Works
Prednisolone is a corticosteroid. It reduces inflammation by reversal of increased capillary permeability and suppresses the polymorphonuclear leukocytes migration. It also affects the lymphatic system by reducing its activity and volume.
Side Effects of Prednisolone
Adrenal suppresion, Fluid and electrolyte disturbances, hyperglycemia, Peptic ulcer, Glaucoma, Depression, Weight gain, Arrest of growth.
Warnings
Kidney Safe If Prescribed
Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed. Please consult your doctor for confirmation.
Alcohol Not Advisable
It is unsafe to consume alcohol with Prednisolone. Taking Prednisolone with alcohol may enhance the gastric mucosal irritation.
Pregnancy Not Safe
Prednisolone may be unsafe to use during pregnancy. Animal studies have shown side effects on the fetus, however, there are limited human studies. Sorticosteroids should only be prescribed when the benefits to the mother and child outweigh the risks. Patients with pre-eclampsia or fluid retention require close monitoring. Please consult your doctor.
Driving Generally Safe
Prednisolone usually does not affect the ability to drive. Do not drive unless you are feeling well.
Liver Safe If Prescribed
The effect of corticosteroids may be enhanced in patients with chronic liver disease with impaired hepatic function.
Lactation Safe If Prescribed
Doses of up to 40mg daily of Prednisolone are unlikely to cause systemic effects in the infant. Infants of mothers receiving 40mg or more daily should be monitored for signs of adrenal suppression but the benefits of breast-feeding are likely to outweigh any theoretical risk.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
