Propylthiouracil
Uses of Propylthiouracil
Propylthiouracil is commonly used to treat Hyperthyroidism
How Propylthiouracil Works
Propylthiouracil is able to bind to thyroid peroxidase which will lead to the prevention of iodide to iodine and incorporation of iodides to thyroglobulin. This mechanism will reduce the production of new thyroid hormones in patients with hyperthyroidism.
Side Effects of Propylthiouracil
Decreased white blood cells/platelets, Lupus-like syndrome, Cutaneous vasculitis, Skin rash, Joint pain, Fever, Gut disturbances, Headache, Agranulocytosis, Aplastic anaemia, Liver dysfunction
Warnings
Kidney Use With Care
Dose adjustment is needed in patients with kidney impairment. Please consult your doctor.
Alcohol Not Advisable
Alcohol may further damage the liver which is caused by Propylthiouracil. Thus, it is not advisable to consume alcohol and Propylthiouracil concomitantly.
Pregnancy Not Safe
Animal studies and human studies have shown reproductive toxicities. Thus, Propylthiouracil is contraindicated during pregnancy.
Driving Generally Safe
There are no studies on the effect of Propylthiouracil on the ability to drive. Do not drive unless you are feeling well.
Liver Use With Care
Dose adjustment is needed in patients with liver impairment. Please consult your doctor.
Lactation Not Advisable
Excretion of Propylthiouracil has been found in human breast milk. Thus, it is contraindicated during breastfeeding.