Prucalopride
Uses of Prucalopride
Prucalopride is commonly used to chronic idiopathic constipation.
How Prucalopride Works
Prucalopride's exerts its effect by binding to selective 5-HT4 receptor, stimulating intestinal secretions, peristaltic reflex, and gastrointestinal motility.
Side Effects of Prucalopride
Headache, Dizziness, Fatigue, Nausea and vomiting, Diarrhea, Abdominal pain, Dyspepsia, Flatulence, Decreased appetite
Warnings
Kidney Use With Care
Prucalopride should be used with caution in patients with severe kidney impairment. Dose adjustment of Prucalopride may be needed for patients with creatinine clearance less than 30 mL/min. Please consult your doctor.
Alcohol Safe
Prucalopride has no effect on the metabolism of alcohol.
Pregnancy Limited Data
Prucalopride is not recommended for the usage of women in the reproductive age who practice unprotected coitus.
Driving Not advisable
Do not drive unless you are feeling well. Prucalopride may cause side effects such as dizziness or tiredness, all of which could affect the ability to concentrate and drive.
Liver Limited Data
You may start Prucalopride with 1 mg once daily for patients with severe hepatic impairment (Child-Pugh class C) and may be increased to 2 mg if tolerated with Prucalopride. However, for patients with mild to moderate liver disease, no dose adjustment is needed.
Lactation Limited Data
Prucalopride is excreted into the breast milk and safe to use during lactation at therapeutic dose. Limited human data suggests that Prucalopride does not represent a significant risk to the baby. Please consult your doctor to be sure.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
