Rilpivirine
Uses of Rilpivirine
Rilpivirine is commonly used to treat HIV Infection
How Rilpivirine Works
Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) which will help to reduce the viral DNA synthesis, leading to the prevention of viral proliferation and viral death.
Side Effects of Rilpivirine
Mental disturbances, Central obesity, Hepatotoxicity, Allergic reactions, Immune reconstitution syndrome, Abdominal pain, Dry mouth, Vomiting, Increased cholesterol and triglyceride level, Decreased red blood cells/white blood cells/platelets, Decreased appetite, Drowsiness
Warnings
Kidney Use With Care
Caution use has to be practised in patients with severe or end-stage kidney disease. Please consult your doctor.
Alcohol Not Advisable
Alcohol is not recommended in the first 4 weeks of therapy and it is not advisable to be used as alcohol will further damage the liver caused by Rilpivirine.
Pregnancy Limited Data
Animal studies have not shown any reproductive toxicities but there are limited data on the use of Rilpivirine in pregnant women. Thus, it is not advisable to be used during pregnancy. Please consult your doctor.
Driving Generally Safe
Rilpivirine usually does not affect the ability to drive. Do not drive unless you are feeling well.
Liver Use With Care
Caution use has to be practised in patients with moderate liver impairment. Rilpivirine is contraindicated in patients with severe liver impairment. Please consult your doctor.
Lactation Not Advisable
Excretion of Rilpivirine has been found in animal milk but it is unknown in human breast milk. An HIV-infected mother is not recommended to breastfeed the baby to prevent transmission and adverse effects of Rilpivirine. Please consult your doctor.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
