Salbutamol
Uses of Salbutamol
Salbutamol/Albuterol is commonly used in the treatment of Asthma and Chronic Obstructive Pulmonary Disease (COPD).
How Salbutamol Works
Salbutamol activates the enzyme that stimulates the production of cAMP. It leads to the activation of protein kinase A, which lowers intracellular ionic Ca concentration and inhibits phosphorylation of myosin. This relaxes the smooth muscle in the airways which relief breathlessness.
Side Effects of Salbutamol
Tremor, Nausea and vomiting, Palpitations, Chest discomfort, Tremors, Dizziness, Headache, Sweating, Hypersensitivity reaction
Warnings
Kidney Use With Care
Salbutamol should be used with caution in patients with severe kidney disease as it may cause hypokalaemia. Dose adjustment of Salbutamol may be needed. Please consult your doctor.
Alcohol Not Advisable
It is unsafe to consume alcohol with Salbutamol. Taking Salbutamol with alcohol may worsen the side effects such as headache, dizziness, lightheadedness, fainting, and/or palpitations.
Pregnancy Not Safe
Salbutamol may be unsafe to use during pregnancy. Animal studies have shown adverse reactions on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable even with the risk. Please consult your doctor.
Driving Generally Safe
Salbutamol usually does not affect the ability to drive. Do not drive unless you are feeling well.
Liver Limited Data
Salbutamol should be safe to use in patients with liver disease. It is rare for most of the antiasthmatic agents to cause hepatotoxicity. No dose adjustment of Salbutamol may be needed.
Lactation Limited Data
Salbutamol excretes in breast milk but it is not known to show any harmful effect on breastfed babies. However, its usage should be restricted unless the benefits outweigh the risks.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
