Sertraline
Uses of Sertraline
Sertraline is commonly used to treat depression, anxiety disorders, obsessive compulsive disorder (OCD), phobias, and post-traumatic stress disorder.
How Sertraline Works
Sertraline is classified as a selective serotonin reuptake inhibitor. It inhibits presynaptic serotonin reuptake. The Increased concentration of serotonin leads to numerous functional changes, improving symptoms of depression, anxiety disorders, obsessive-compulsive disorder phobia and post-traumatic stress disorders.
Side Effects of Sertraline
Palpitations, Jaundice, Hypoglycaemia, Hypercholesterolaemia, Hypertension, Hyperglycaemia, Menstrual irregularities, Urinary incontinence, Tinnitus
Warnings
Kidney Safe If Prescribed
No dosage adjustments required at any degree of kidney impairment.
Alcohol Not Advisable
It is unsafe to consume alcohol with Sertraline. Taking Sertraline with alcohol may increase the risk of neurological impairment.
Pregnancy Not Safe
Although there is a significant amount of data showing that Sertraline would not cause congenital malformations, but has been reported to cause withdrawal reactions in some neonates. Hence, Sertraline usage is not recommended during pregnancy. Please consult your doctor.
Driving Not advisable
Do not drive unless you are feeling well. Sertraline may cause side effects such as dizziness, headches, nausea or palpitations, all of which could affect the ability to concentrate and drive.
Liver Use With Care
Sertraline should be used with caution in patients with liver disease. Dose adjustment of Sertraline may be needed for patients with mild and moderate liver disease. In patients with severe hepatic impairment, Sertraline should be avoided. Please consult your doctor.
Lactation Not Advisable
To date, there are no reported adverse effects on the health of breastfed infants although it is known to be secreted into the breastmilk. However, its usage is not recommended unless the benefits outweigh the risks.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
