Tadalafil
Uses of Tadalafil
Tadalafil is commonly used in the treatment of erectile dysfunction, benign prostatic hyperplasia and pulmonary artery hypertension
How Tadalafil Works
Tadalafil is a phosphodiesterase (PDE) inhibitor specifically PDE-5. Inhibition of this enzyme causes the end result of relaxation of smooth muscle and increase in blood flow in the penile muscle, prostatic tissue and in the pulmonary vascular bed.
Side Effects of Tadalafil
Low blood pressure, Chest pain, Headache, Palpitations, Vision loss, Ringing of the ear, Limbs swelling, Dizziness
Warnings
Kidney Use With Care
Use of Tadalafil in renal impairment patients should be monitored closely with dose adjustment is recommended.
Alcohol Not Advisable
It is not advisable to consume alcohol together with Tadalafil as it can cause further reaction such as hypotension, dizziness and palpitations.
Pregnancy Maybe Safe
Animal studies failed to demonstrate a direct or indirect effect on reproductive toxicity and there are inadequate human studies on the usage of Tadalafil in pregnancy. It is, however, best avoided to use Tadalafil unless the benefit outweigh the risks.
Driving Generally Safe
Tadalafil usually does not affect the ability to drive. Do not drive unless you are feeling well.
Liver Use With Care
It is advisable to adjust the dose of Tadalafil in mild to moderate hepatic impairment patients and the use of Tadalafil is not recommended in severe liver disease.
Lactation Not Advisable
Animals studies have shown the excretion of Tadalafil in the breast milk. Therefore, it is advisable not to use Tadalafil in breastfeeding women or breastfeeding alternatives should be sought if treatment of Tadalafil is highly indicated.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
