Temozolomide
Uses of Temozolomide
Temozolomide is commonly used to treat Brain Tumor and Malignant Melanoma.
How Temozolomide Works
Temozolomide is a triazene (inactive prodrug) which can be hydrolyzed into MTIC and causing alkylation of guanine in the DNA strands. Thus, this helps to control the progression of brain tumours such as malignant gliomas and glioblastoma multiforme and also metastatic melanoma.
Side Effects of Temozolomide
Nausea and vomiting, Taste disturbances, Gut disturbances, Anorexia, Hyperglycaemia, Weight loss, Headache, Blurred vision, Hearing disturbances, Oedema, Skin rash, Urinary incontinence, Liver enzyme dysfunction
Warnings
Kidney Use With Care
Caution use of Temozolomide has to be practised in patients with kidney impairment. Please consult your doctor.
Alcohol Not Advisable
There are no known interactions between alcohol and Temozolomide when used concomitantly. However, it is not advisable to consume alcohol during the treatment of cancer-related diseases. Please consult your doctor.
Pregnancy Not Safe
Animal studies have shown reproductive toxicities but there are no clinical data on the use of Temozolomide on pregnant women. Thus, it is not advisable to use Temozolomide during pregnancy. Please consult your doctor.
Driving Not advisable
Do not drive unless you are feeling well. Temozolomide may cause side effects such as tiredness and sleepiness, all of which could affect your ability to concentrate and drive.
Liver Limited Data
Caution use of Temozolomide has to be practised in patients with severe liver impairment. Please consult your doctor.
Lactation Limited Data
The excretion of Temozolomide is not known in human milk. Thus, it is not advisable to use Temozolomide during breastfeeding. Please consult your doctor.