Tiotropium
Uses of Tiotropium
Tiotropium is commonly used to treat Asthma, Chronic Obstructive Pulmonary Disease (COPD)
How Tiotropium Works
Tiotropium is an antimuscarinic agent which inhibits the muscarinic receptors especially the M3 receptors found in the smooth muscle of the lungs. This will cause smooth muscle relaxation and dilates the airway.
Side Effects of Tiotropium
Dry mouth, Allergy reaction, Dizziness, Hoarseness of voice, Palpitation, Visual disturbances, Lung infections
Warnings
Kidney Use With Care
Dose adjustment is needed in patients with moderate to severe kidney impairment.
Alcohol Not Advisable
There is no known interaction between alcohol and Tiotropium when consumed concomitantly. However, alcohol will also cause dizziness, blurring of vision and dry mouth which may be additive to patients suffering from side effects of Tiotropium.
Pregnancy Not Safe
Animal studies have not shown any reproductive toxicities and there are limited data of Tiotropium on pregnant women. Thus, Tiotropium is not advisable to be used during pregnancy. Please consult your doctor.
Driving Generally Safe
There are no studies on the effect of Tiotropium on the ability to drive. Do not drive unless you are feeling well.
Liver Use With Care
Tiotropium is safe to be used in patients with liver impairment.
Lactation Not Advisable
Animal studies have shown a small amount of excretion of Tiotropium in animal milk but it is unknown in human milk. Thus, Tiotropium is not advisable during breastfeeding. Please consult your doctor.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
