Trihexyphenidyl
Uses of Trihexyphenidyl
Trihexyphenidyl/Benzhexol is commonly used to treat Drug Induced Abnormal Movements and Parkinson's Disease.
How Trihexyphenidyl Works
Trihexyphenidyl/Benzhexol is a selective M1 central muscarinic receptor antagonist. It inhibits the cholinergic activity and increases the dopamine level in the central nervous system which helps to provide smooth control of voluntary muscle movements.
Side Effects of Trihexyphenidyl
Mouth dryness, Flushing, Skin dryness, Dilated pupils, Tachycardia, Hypertension, Neurological disturbances
Warnings
Kidney Use With Care
Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor.
Alcohol Not Advisable
It is not advisable to consume alcohol and Trihexyphenidyl concomitantly as alcohol will accentuate the sedative effects and tachycardia.
Pregnancy Not Safe
There are insufficient studies on the use of Trihexyphenidyl during pregnancy in animal studies and human studies. Thus, it is not advisable to be used during pregnancy unless it is necessary. Please consult your doctor.
Driving Not advisable
Do not drive unless you are feeling well. Trihexyphenidyl may cause side effects such as dizziness, blurring of vision or nausea, all of which could affect your ability to concentrate and drive.
Liver Limited Data
Dose adjustment may be needed in patients with liver impairment. Please consult your doctor.
Lactation Limited Data
There are insufficient studies on the secretion of Trihexyphenidyl in body milk from animal studies and human studies. Thus, it is not advisable to be used during breastfeeding. Please consult your doctor.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
