Vonoprazan
Uses of Vonoprazan
Vonoprazan is commonly used to treat Helicobacter Pylori H.Pylori Infection, Intestinal Ulcers, Reflux Esophagitis
How Vonoprazan Works
Vonoprazan is a potassium-competitive acid blocker which binds to the proton pump of gastric parietal cells, leading to higher gastric pH by preventing gastric acid production.
Side Effects of Vonoprazan
Altered bowel habits, Bloating, Taste disturbance, Jaundice, Increased liver enzyme, Allergy reaction, Skin rash
Warnings
Kidney Use With Care
Dose adjustment may be needed in patients with kidney impairment.
Alcohol Not Advisable
There is no known interaction between Vonoprazan and alcohol. However, alcohol intake is not advisable as it may worsen conditions to be treated by Vonoprazan.
Pregnancy Limited Data
Animal studies have shown reproductive toxicity but there are no clinical studies of Vonoprazan use in pregnant women. Thus, it is not advisable to be used during pregnancy unless benefits outweigh the risks.
Driving Generally Safe
There are no studies of Vonoprazan on the ability to drive. Do not drive unless you are feeling well.
Liver Limited Data
Dose adjustment of Vonoprazan may be needed in patients with liver impairment.
Lactation Limited Data
Animal studies have shown that Vonoprazan is excreted in animal milk but it is unknown whether Vonoprazan is excreted in human milk. Thus, breastfeeding is not recommended while receiving Vonoprazan treatment.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
